Textbook of Clinical Trials in Oncology

There is an increasing need for educational resources for statisticians and investigators. Reflecting this, the goal of this book is to provide readers with a sound foundation in the statistical design, conduct, and analysis of clinical trials. Furthermore, it is intended as a guide for statisticians and investigators with minimal clinical trial experience who are interested in pursuing a career in this area. The advancement in genetic and molecular technologies have revolutionized drug development. In recent years, clinical trials have become increasingly sophisticated as they incorporate genomic studies, and efficient designs (such as basket and umbrella trials) have permeated the field. This book offers the requisite background and expert guidance for the innovative statistical design and analysis of clinical trials in oncology.Key Features:Cuttingedge topics with appropriate technical backgroundBuilt around case studies which give the work a handson approachReal examples of flaws in previously reported clinical trials and how to avoid themAccess to statistical code on the books websiteChapters written by internationally recognized statisticians from academia and pharmaceutical companiesCarefully edited to ensure consistency in style, level, and approachTopics covered include innovating phase I and II designs, trials in immuneoncology and rare diseases, among many others